Expression of embryonic stem cell markers in human term placenta / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 700-706, 2009.
Article
in Korean
| WPRIM
| ID: wpr-193714
ABSTRACT
OBJECTIVE:
To determine which compartments of placenta in the term pregnancy express the embryonic stem cell markers.METHODS:
We have used immunohistochemical methods with antibodies to embryonic stem cell surface antigens, TRA 1-60 (Tumor rejection antigen 1-60), TRA 1-81 (Tumor rejection antigen 1-81), SSEA-3 (stage-specific embryonic antigen-3) and SSEA-4 (stage-specific embryonic antigen-4), to identify and localize stem cells in the term placenta.RESULTS:
Stem cell marker-positive cells were found in all layer of placenta. Amnionic epithelial cells was immunoreactive with TRA 1-60, TRA 1-81. Amnionic mesenchymal stromal cells was immunoreactive with TRA 1-81. Chorionic mesenchymal stromal cells was immunoreactive with TRA 1-60 and TRA 1-81. SSEA-3 and SSEA-4 were not stained at any compartment of the term placenta. Compartment that was stained most strongly by TRA 1-60 was the amnionic epithelial cells layer. Compartment that was stained most strongly by TRA 1-81 was the chorionic mesenchymal stromal cells layer.CONCLUSION:
The mesenchymal stroma cells of the amnion and chorion as well as amnionic epithelial cells may be useful source of pluripotent stem cells in the term placenta.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Placenta
/
Rejection, Psychology
/
Stem Cells
/
Antigens, Tumor-Associated, Carbohydrate
/
Chorion
/
Pluripotent Stem Cells
/
Epithelial Cells
/
Embryonic Stem Cells
/
Stage-Specific Embryonic Antigens
/
Mesenchymal Stem Cells
Limits:
Humans
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2009
Type:
Article
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