The Clinical and Laboratory Characteristics of Patients with Chronic Hepatitis B Using Current or Past Antiviral Therapy in Korea: A Multi-Center, Nation-Wide, Cross-Sectional Epidemiologic Study
Gut and Liver
;
: 241-248, 2012.
Article
in English
| WPRIM
| ID: wpr-19381
ABSTRACT
BACKGROUND/AIMS:
The proper assessment of the current disease status of patients with chronic hepatitis B would be valuable for establishing optimal management strategies.METHODS:
The clinical and laboratory characteristics of 2,954 patients with current or previous antiviral treatment (46.2+/-10.8 years, 69.7% male) enrolled from 46 referral hospitals and 129 local hospitals or clinics throughout Korea were analyzed.RESULTS:
The disease status included chronic hepatitis, cirrhosis, and hepatocellular carcinoma in 79.9%, 16.4%, and 3.7% of the patients, respectively. The major mode of hepatitis B virus (HBV) infection was vertical transmission. The hepatitis C virus (HCV) co-infection rate was 1.5%; however, only 50.8% of patients were evaluated for HCV. The use of herbal or complementary medicines was reported in 33.5% of the patients. The majority of patients (97.6%) were treated with oral nucleoside/nucleotide analogues. Several characteristics were different between the patients treated at referral hospitals and local hospitals/clinics, including the disease state, choice of antiviral drug, and methods of HBV DNA measurement.CONCLUSIONS:
This study provides a comprehensive picture of the clinical and laboratory characteristics of patients treated in Korea. Efforts to optimize management strategies are warranted.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Referral and Consultation
/
Fibrosis
/
DNA
/
Epidemiologic Studies
/
Hepatitis B virus
/
Hepacivirus
/
Carcinoma, Hepatocellular
/
Hepatitis B, Chronic
/
Coinfection
/
Hepatitis, Chronic
Type of study:
Controlled clinical trial
/
Observational study
/
Prevalence study
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Gut and Liver
Year:
2012
Type:
Article
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