The Role of Macrophage Lipophagy in Reverse Cholesterol Transport
Endocrinology and Metabolism
;
: 41-46, 2017.
Article
in English
| WPRIM
| ID: wpr-194432
ABSTRACT
Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes. In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target in the treatment of atherosclerosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autophagy
/
Cholesterol
/
Atherosclerosis
/
Lipid Droplets
/
Foam Cells
/
Homeostasis
/
Hydrolysis
/
Lysosomes
/
Macrophages
Language:
English
Journal:
Endocrinology and Metabolism
Year:
2017
Type:
Article
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