Update on Familial Hypercholesterolemia: Diagnosis, Cardiovascular Risk, and Novel Therapeutics
Endocrinology and Metabolism
;
: 36-40, 2017.
Article
in English
| WPRIM
| ID: wpr-194433
ABSTRACT
In recent studies, the reported prevalence of heterozygous familial hypercholesterolemia (FH) has been higher than in previous reports. Although cascade genetic screening is a good option for efficient identification of affected patients, diagnosis using only clinical criteria is more common in real clinical practice. Cardiovascular risk is much higher in FH patients due to longstanding low density lipoprotein cholesterol (LDL-C) burden and is also influenced by other risk factors. Although guidelines emphasize aggressive LDL-C reduction, the majority of patients cannot reach the LDL-C goal by conventional pharmacotherapy. Novel therapeutics such as proprotein convertase subtilisin/kexin type 9 inhibitors have shown strong lipid lowering efficacy and are expected to improve treatment results in FH patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Genetic Testing
/
Prevalence
/
Risk Factors
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Coronary Disease
/
Proprotein Convertases
/
Diagnosis
/
Drug Therapy
/
Genetics
/
Hyperlipoproteinemia Type II
Type of study:
Diagnostic study
/
Etiology study
/
Practice guideline
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Endocrinology and Metabolism
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS