Y chromosome microdeletions in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome
Experimental & Molecular Medicine
;
: 231-234, 2000.
Article
in English
| WPRIM
| ID: wpr-194515
ABSTRACT
The objective of this study was to elucidate the cause of the spermatogenic defect in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome. Genomic DNAs from 9 cases of Korean idiopathic azoospermia and 6 of Korean non-mosaic type of Klinefelter syndrome were used for the detection of Y chromosome microdeletions by polymerase chain reaction using 60 primers. Microdeletions of the Y chromosome were found in 1 of 9 (11.1%) patients with idiopathic azoospermia, whereas none was deleted in non-mosaic type of Klinefelter syndrome. This result suggests that Y chromosome microdeletions could be one of the etiologic factors in idiopathic azoospermia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oligospermia
/
Spermatogenesis
/
X Chromosome
/
Y Chromosome
/
Polymerase Chain Reaction
/
Sequence Tagged Sites
/
Sequence Deletion
/
Gene Dosage
/
Klinefelter Syndrome
Limits:
Humans
/
Male
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2000
Type:
Article
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