Association of citalopram with congenital anomalies: A meta-analysis
Obstetrics & Gynecology Science
;
: 145-153, 2017.
Article
in English
| WPRIM
| ID: wpr-194743
ABSTRACT
OBJECTIVE:
The antenatal use of citalopram, a widely prescribed selective serotonin reuptake inhibitor, has been suspected to be associated with congenital, particularly cardiac, anomalies. This study aimed to prove the association between citalopram use and congenital anomalies.METHODS:
We searched the English literature from July 1998 to July 2015, by using the search terms ‘ citalopram’, ‘ pregnancy’, ‘ birth defects’, ‘ congenital anomalies’, and ‘ malformations’ in PubMed, Embase, Web of Science, and the Cochrane Library.RESULTS:
Eight eligible articles were analyzed including a total of 1,507,896 participants. The odds ratio (OR) of major malformations associated with citalopram use during pregnancy was 1.07 (95% confidence interval [CI], 0.98 to 1.17). Concerning cardiac malformations, the OR for all included studies was 1.31 (95% CI, 0.88 to 1.93). The analysis of cardiac malformations was repeated to reduce heterogeneity after excluding one outlier study (OR, 1.03; 95% CI, 0.84 to 1.26).CONCLUSION:
From our data, it can be concluded that citalopram use is not associated with major birth defects. However, physicians should carefully weigh the benefits against the potential risks of citalopram use, and counsel patients accordingly.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Congenital Abnormalities
/
Population Characteristics
/
Citalopram
/
Serotonin
/
Odds Ratio
/
Parturition
Type of study:
Etiology study
/
Systematic reviews
Limits:
Humans
/
Pregnancy
Language:
English
Journal:
Obstetrics & Gynecology Science
Year:
2017
Type:
Article
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