Optical Coherence Tomography-angiography: Comparison of the Foveal Avascular Zone between Diabetic Retinopathy and Normal Subjects
Journal of the Korean Ophthalmological Society
;
: 952-959, 2017.
Article
in Korean
| WPRIM
| ID: wpr-194880
ABSTRACT
PURPOSE:
To evaluate the effectiveness of optical coherence tomography angiography (OCTA) in investigating changes in the area of the foveal avascular zone (FAZ) in patients with diabetic retinopathy (DR) and normal subjects.METHODS:
Eighty-five eyes of 50 DR patients and 50 eyes of 25 normal subjects were included. OCTA images of the FAZ were acquired using the split-spectrum amplitude decorrelation angiography algorithm of Optovue Avanti RTVue XR OCT. Patients were divided into three groups according to DR severity mild-to-moderate non-proliferative diabetic retinopathy (NPDR) group, severe NPDR group, and proliferative DR group. The area of the FAZ was measured using built-in software and was compared between the patients and normal subjects and among the three groups.RESULTS:
The area of the FAZ in patients with diabetic retinopathy (0.46 mm²) was significantly larger than that in normal subjects (0.30 mm², p = 0.001). A significant difference was observed depending on DR severity 0.40 mm² in the mild-to-moderate NPDR group, 0.45 mm² in the severe NPDR group, and 0.53 mm² in the PDR group (p = 0.03). Correlation between area of the foveal avascular zone and visual acuity showed a tendency toward reduction in visual acuity (p = 0.002).CONCLUSIONS:
OCTA effectively detected changes in the FAZ area in DR patients. OCTA has the potential to be used for noninvasive quantification and monitoring of the FAZ.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Angiography
/
Visual Acuity
/
Tomography, Optical Coherence
/
Diabetic Retinopathy
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2017
Type:
Article
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