Effects of Calcitriol on Delayed Neuronal Damage of Hippocampus in Transient Global Ischemia Model of Mature Gerbil
Korean Journal of Pathology
;
: 307-315, 2003.
Article
in Korean
| WPRIM
| ID: wpr-194899
ABSTRACT
BACKGROUND:
It is well documented that calcium ions perform a major role in neuronal degeneration in cerebrovascular disease and the other degenerative diseases, and that 1,25-dihydroxyvitamin D3 (D3) has the dose-dependent protective effects. This study was performed to examine the effects of different D3 dosages against delayed neuronal damage of the hippocampus.METHODS:
Mature mongolian gerbils were injected with either 0.8 microgram/kg/day (group 2) for 5 days or 1.0 microgram/kg/day for 8 days (group 3) prior to the 10 min ligation of the bilateral common carotid arteries. Immunohistochemical expression for the glial cell line-derived neurotrophic factor (GDNF), the basic fibroblast growth factor (bFGF) and the platelet-derived neurotrophic factor (PDNF) was observed in the D3-injected (0.8 microgram/kg/day for 5 days) group.RESULTS:
Group 2 showed a highly significant attenuation of delayed neuronal damage in the lateral CA1 region at 7 days after reperfusion. Group 3 showed unilateral or bilateral hemispheric infarcts 24 h after the onset of reperfusion. The D3-injected group showed a markedly increased bFGF expression level.CONCLUSION:
The dose-dependent effect of D3 suggests the importance of determining the appropriate D3 dose for clinical applications. Although the mechanism(s) of neuroprotection by D3 remains unclear, D3 may facilitate a reduction in ischemia-induced oxidative stress via the activation of the neurotrophic factors, including bFGF and GDNF.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Calcitriol
/
Reperfusion
/
Cerebrovascular Disorders
/
Calcium
/
Fibroblast Growth Factor 2
/
Gerbillinae
/
Carotid Artery, Common
/
Oxidative Stress
/
Glial Cell Line-Derived Neurotrophic Factor
/
Hippocampus
Type of study:
Prognostic study
Language:
Korean
Journal:
Korean Journal of Pathology
Year:
2003
Type:
Article
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