Clinical Significance of C4d-Positivity in Renal Transplant Recipients with Acute Rejection / 대한이식학회지
The Journal of the Korean Society for Transplantation
;
: 137-141, 2005.
Article
in Korean
| WPRIM
| ID: wpr-194943
ABSTRACT
PURPOSE:
C4d detection in peritubular capillaries in acute allograft rejection has been regarded as a poor prognostic factor for graft kidney survival. We investigated the clinical importance of C4d positivity in renal transplant recipients with acute rejection.METHODS:
Forty eight renal allograft biopsies were selected, which were available for immunofluorescence study. The samples were divided into two groups, one which was diagnosed as acute rejection clinically (n=30), the other which underwent protocol biopsy 2 weeks after transplantation (n=18). Among the acute rejection group, C4d staining was positive in 50% of acute rejection cases (C4d (+), n=15) and negative in the others. (C4d (-), n=15). We compared the C4d (+) group and the C4d (-) group in terms of clinical parameters and graft survival duration.RESULTS:
Renal function was reduced in the C4d (+) group compared to the C4d (-) group. In the C4d (+) group, 8 of 15 cases resulted in graft loss, but only one graft loss developed in the C4d (-) group. Graft survival duration after kidney biopsy was reduced in the C4d (+) group compared to the C4d (-) group.CONCLUSION:
Renal transplant recipient with C4d-positive acute rejection shows inferior graft survival duration. So tight management in addition to steroid pulse therapy should be considered for these patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transplantation
/
Biopsy
/
Capillaries
/
Fluorescent Antibody Technique
/
Kidney Transplantation
/
Transplants
/
Allografts
/
Graft Survival
/
Kidney
Type of study:
Practice guideline
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
The Journal of the Korean Society for Transplantation
Year:
2005
Type:
Article
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