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Efficacy of Levofloxacin-Based Third-Line Therapy for the Eradication of Helicobacter pylori in Peptic Ulcer Disease
Gut and Liver ; : 226-231, 2017.
Article in English | WPRIM | ID: wpr-194966
ABSTRACT
BACKGROUND/

AIMS:

The resistance rate of Helicobacter pylori is gradually increasing. We aimed to evaluate the efficacy of levofloxacin-based third-line H. pylori eradication in peptic ulcer disease.

METHODS:

Between 2002 and 2014, 110 patients in 14 medical centers received levofloxacin-based third-line H. pylori eradication therapy for peptic ulcer disease. Of these, 88 were included in the study; 21 were excluded because of lack of follow-up and one was excluded for poor compliance. Their eradication rates, treatment regimens and durations, and types of peptic ulcers were analyzed.

RESULTS:

The overall eradiation rate was 71.6%. The adherence rate was 80.0%. All except one received a proton-pump inhibitor, amoxicillin, and levofloxacin. One received a proton-pump inhibitor, amoxicillin, levofloxacin, and clarithromycin, and the eradication was successful. Thirty-one were administered the therapy for 7 days, 25 for 10 days, and 32 for 14 days. No significant differences were observed in the eradication rates between the three groups (7-days, 80.6% vs 10-days, 64.0% vs 14-days, 68.8%, p=0.353). Additionally, no differences were found in the eradiation rates according to the type of peptic ulcer (gastric ulcer, 73.2% vs duodenal/gastroduodenal ulcer, 68.8%, p=0.655).

CONCLUSIONS:

Levofloxacin-based third-line H. pylori eradication showed efficacy similar to that of previously reported first/second-line therapies.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Peptic Ulcer / Ulcer / Follow-Up Studies / Helicobacter pylori / Helicobacter / Clarithromycin / Compliance / Levofloxacin / Amoxicillin Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Gut and Liver Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Peptic Ulcer / Ulcer / Follow-Up Studies / Helicobacter pylori / Helicobacter / Clarithromycin / Compliance / Levofloxacin / Amoxicillin Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Gut and Liver Year: 2017 Type: Article