Frontier of Epilepsy Research - mTOR signaling pathway
Experimental & Molecular Medicine
;
: 231-274, 2011.
Article
in English
| WPRIM
| ID: wpr-19500
ABSTRACT
Studies of epilepsy have mainly focused on the membrane proteins that control neuronal excitability. Recently, attention has been shifting to intracellular proteins and their interactions, signaling cascades and feedback regulation as they relate to epilepsy. The mTOR (mammalian target of rapamycin) signal transduction pathway, especially, has been suggested to play an important role in this regard. These pathways are involved in major physiological processes as well as in numerous pathological conditions. Here, involvement of the mTOR pathway in epilepsy will be reviewed by presenting; an overview of the pathway, a brief description of key signaling molecules, a summary of independent reports and possible implications of abnormalities of those molecules in epilepsy, a discussion of the lack of experimental data, and questions raised for the understanding its epileptogenic mechanism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Binding
/
Synapses
/
Temporal Lobe
/
Signal Transduction
/
Astrocytes
/
Cell Death
/
Receptors, Cannabinoid
/
Protein Kinase Inhibitors
/
Epilepsy
/
Diet, Ketogenic
Limits:
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2011
Type:
Article
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