Role of Photodynamic Therapy in the Palliation of Obstructing Esophageal Cancer
The Korean Journal of Internal Medicine
;
: 278-284, 2012.
Article
in English
| WPRIM
| ID: wpr-195166
ABSTRACT
BACKGROUND/AIMS:
The aim of this non-randomized study was to determine the role of photodynamic therapy (PDT) in a multimodal approach for the palliation of advanced esophageal carcinoma.METHODS:
Twenty consecutive patients with obstructing esophageal cancer were enrolled in this study. Each subject had dysphagia, and nine could not swallow fluid. External beam radiotherapy or a self-expandable metal stent was used following PDT for dysphagia due to recurrence of the malignancy.RESULTS:
At 4 weeks post-PDT, a significant improvement in the dysphagia score was observed in 90% of patients, from 2.75 +/- 0.91 to 1.05 +/- 0.83 (p < 0.05). Patients with recurrent dysphagia underwent stent insertion at an average of 63 days (range, 37 to 90). The rate of major complications was 10%. Two esophageal strictures occurred, which were treated by placement of a modified expandable stent across the stricture. The median survival in these cases was 7.0 +/- 0.6 months. One patient that was treated with PDT and radiotherapy is alive and showed a complete tumor response.CONCLUSIONS:
PDT as a multimodality treatment is safe and effective for relieving malignant esophageal obstruction with minimal complications.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Palliative Care
/
Photochemotherapy
/
Prosthesis Design
/
Time Factors
/
Biopsy
/
Esophageal Neoplasms
/
Carcinoma, Squamous Cell
/
Adenocarcinoma
/
Deglutition Disorders
/
Stents
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2012
Type:
Article
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