Analysis of Cytokines in Sera from Type 1 Diabetic Patients at Diagnosis / 대한소아내분비학회지
Journal of Korean Society of Pediatric Endocrinology
;
: 13-19, 2011.
Article
in Korean
| WPRIM
| ID: wpr-195208
ABSTRACT
PURPOSE:
Diverse cytokines influence the pathogenesis of type 1 diabetes mellitus (T1DM) in different ways. We studied the profile of cytokines in sera from type 1 diabetic patients at diagnosis.METHODS:
Serum levels of 11 cytokines (IL-1alpha, IL-1beta, IL-1Ra, IL-2, IL-4, IL-6, IL-10, IL-12 (p70), INF-gamma, and TNF-alpha) from 38 newly-diagnosed T1DM patents and 39 healthy controls were measured, using multiplex immunoanalytic xMAP.RESULTS:
Patients showed significantly higher levels of IL-1beta (P < 0.01), IL-10 (P < 0.01), and TNF-alpha (P = 0.019), than the healthy controls. In 12 of 35 patients, the insulin autoantibody (IAA) was positive (34%) and the level of IAA was correlated with IL-10 (r = 0.454, P = 0.006), and TNF-alpha (r = 0.368, P = 0.030).CONCLUSION:
These results suggest that IL-1beta, TNF-alpha, and IL-10 play a role in the pathogenesis of T1DM, and the level of the IAA is correlated with IL-10 and TNF-alpha.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoantibodies
/
Cytokines
/
Interleukin-4
/
Interleukin-6
/
Interleukin-2
/
Tumor Necrosis Factor-alpha
/
Interleukin-10
/
Interleukin-12
/
Diabetes Mellitus, Type 1
/
Interleukin 1 Receptor Antagonist Protein
Type of study:
Diagnostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Society of Pediatric Endocrinology
Year:
2011
Type:
Article
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