Reduced Venous Blood Basophil Count and Anxious Depression in Patients with Major Depressive Disorder
Psychiatry Investigation
;
: 321-326, 2016.
Article
in English
| WPRIM
| ID: wpr-19527
ABSTRACT
OBJECTIVE:
Anxious depression has a distinct neurobiology, clinical course and treatment response from non-anxious depression. Role of inflammation in anxious depression has not been examined. As an exploratory study to characterize the role of inflammation on a development of anxious depression, we aimed to determine the relationship between white blood cell (WBC) subset counts and anxiety in individuals with major depressive disorder (MDD).METHODS:
A total of 709 patients who were newly diagnosed with MDD were recruited. Anxiety levels of participants were evaluated using the Anxiety/ Somatization subitem of the Hamilton Depression Rating Scale. The association between WBC subset fraction and anxiety was evaluated.RESULTS:
Basophil and eosinophil sub-fractions showed significant negative correlations with HAM-D anxiety/somatization factor scores (basophils r=-0.092, p=0.014 and eosinophils r=-0.075, p=0.046). When an anxiety score (a sum of somatic and psychic anxiety) was entered as a dependent variable, only basophils showed significant negative association with the anxiety scores after adjusting for all other WBC subset counts and demographic factors (t=-2.57, p=0.010).CONCLUSION:
This study showed that anxious depression had a decreased basophil subfraction, which might be associated with involvement of inflammation in development of anxious depression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Anxiety
/
Basophils
/
Neurobiology
/
Demography
/
Depression
/
Depressive Disorder, Major
/
Eosinophils
/
Inflammation
/
Leukocytes
Limits:
Humans
Language:
English
Journal:
Psychiatry Investigation
Year:
2016
Type:
Article
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