Neuroprotective effect of memantine in a rabbit model of optic nerve ischemia
Korean Journal of Ophthalmology
;
: 1-7, 2002.
Article
in Korean
| WPRIM
| ID: wpr-195373
ABSTRACT
The purpose of this study was to evaluate the neuroprotective effect of memantine, a N-methyl-D-aspartate antagonist, in an experimental optic nerve ischemia. Endothelin-1 (ET-1) in a dosage of 0.1 microg/day was delivered to the perineural region of the anterior optic nerve by osmotically driven minipumps for 8 weeks in 10 rabbits. In 5 rabbits, 1 mg/kg memantine was administered concurrently by intramuscular injection once a daily. Morphologic optic nerve head changes were monitored with a confocal scanning laser ophthalmoscope. Multivariate statistical analysis showed a significant change in topometric parameters (cup area, cup depth and rim volume), indicating an increase in optic nerve head cupping and a decrease of neural rim volume in the ET-1 administered eyes (P < 0.0001). In rabbits where memantine was given concurrently with ET-1, no significant change in topometric parameters was observed after ET-1 administration (P = 0.78). The current results suggest that memantine has a neuroprotective effect in optic nerve ischemia. Memantine may potentially be useful in the management of various ischemic disorders of the optic nerve, including glaucoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Optic Disk
/
Optic Nerve
/
Comparative Study
/
Memantine
/
Neuroprotective Agents
/
Excitatory Amino Acid Antagonists
/
Optic Neuropathy, Ischemic
/
Endothelin-1
/
Models, Animal
/
Animals
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Ophthalmology
Year:
2002
Type:
Article
Similar
MEDLINE
...
LILACS
LIS