Low Serum Vitamin D Is Associated with Anti-Thyroid Peroxidase Antibody in Autoimmune Thyroiditis
Yonsei Medical Journal
;
: 476-481, 2014.
Article
in English
| WPRIM
| ID: wpr-19538
ABSTRACT
PURPOSE:
The association between autoimmune thyroid diseases (AITDs) and vitamin D deficiency is controversial. We aimed to evaluate the relationship between serum 25-hydroxy-vitamin D3 [25(OH)D3] and anti-thyroid antibody levels. MATERIALS ANDMETHODS:
25(OH)D3, anti-thyroid antibodies, and thyroid function measured in 304 patients who visited the endocrinology clinic were analyzed. The patients were subgrouped into the AITDs or non-AITDs category according to the presence or absence of anti-thyroid antibodies. The relationship between anti-thyroid peroxidase antibody (TPOAb) and 25(OH)D3 was evaluated.RESULTS:
The patients with elevated anti-thyroid antibodies had lower levels of serum 25(OH)D3 than those who did not (12.6+/-5.5 ng/mL vs. 14.5+/-7.3 ng/mL, respectively, p<0.001). Importantly, after adjusting for age, sex, and body mass index, a negative correlation (r=-0.252, p<0.001) was recognized between 25(OH)D3 and TPOAb levels in the AITDs group, but this correlation did not exist in the non-AITDs group (r=0.117, p=0.127). 25(OH)D3 level was confirmed as an independent factor after adjusting for co-factors that may affect the presence of TPOAb in the AITDs group.CONCLUSION:
25(OH)D3 level is an independent factor affecting the presence of TPOAb in AITDs. The causal effect of 25(OH)D3 deficiency to AITDs is to be elucidated.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thyroid Diseases
/
Thyroid Gland
/
Vitamin D
/
Vitamin D Deficiency
/
Vitamins
/
Thyroiditis, Autoimmune
/
Body Mass Index
/
Peroxidase
/
Endocrinology
/
Methods
Limits:
Humans
Language:
English
Journal:
Yonsei Medical Journal
Year:
2014
Type:
Article
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