Apoptotic Effect of Macrophages against Mycobacterium tuberculosis
Journal of Bacteriology and Virology
; : 312-318, 2016.
Article
in Ko
| WPRIM
| ID: wpr-195567
Responsible library:
WPRO
ABSTRACT
Mycobacterium tuberculosis (Mtb) causing tuberculosis as an intracellular pathogen initially infects alveolar macrophages following aerosol inhalation. Thus, macrophages play a critical role in the establishment of Mtb infection and macrophage cell death, a common outcome during Mtb infection, may initiate host- or pathogen-favored immune responses, resulting in facilitating protection or pathogenesis, respectively. In addition, virulent Mtb strains are known to inhibit apoptosis and consequently down-regulates immune response using a variety of strategies. In many recent studies have shown that virulent Mtb can either augment or reduce apoptosis by regulating expression of pro-apoptotic and anti-apoptotic proteins belonging to Bcl-2 family proteins. In this review, we will discuss and dissect the apoptotic pathways of Bcl-2 family proteins in Mtb-infected macrophages.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Tuberculosis
/
Inhalation
/
Macrophages, Alveolar
/
Cell Death
/
Apoptosis
/
Apoptosis Regulatory Proteins
/
Macrophages
/
Mycobacterium
/
Mycobacterium tuberculosis
Limits:
Humans
Language:
Ko
Journal:
Journal of Bacteriology and Virology
Year:
2016
Type:
Article