Advantages of the single nucleotide polymorphism-based noninvasive prenatal test
Journal of Genetic Medicine
;
: 66-71, 2015.
Article
in English
| WPRIM
| ID: wpr-195769
ABSTRACT
Down syndrome screening with cell-free DNA (cfDNA) in the maternal plasma has recently received much attention in the prenatal diagnostic field. Indeed, a large amount of evidence has already accumulated to show that screening tests with cfDNA are more sensitive and specific than conventional maternal serum and/or ultrasound screening. Globally, more than 1,000,000 of these noninvasive prenatal tests (NIPTs) have been performed to date. There are several different methods for NIPTs that are currently commercially available, including shotgun massively parallel sequencing, targeted massively parallel sequencing, and single nucleotide polymorphism (SNP)-based methods. All of these methods have their own advantages and disadvantages. In this review, I will focus specifically on the SNP-based NIPT.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Prenatal Diagnosis
/
DNA
/
Mass Screening
/
Ultrasonography
/
Down Syndrome
/
Polymorphism, Single Nucleotide
/
High-Throughput Nucleotide Sequencing
Type of study:
Diagnostic study
/
Screening study
Language:
English
Journal:
Journal of Genetic Medicine
Year:
2015
Type:
Article
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