Paracentric Inversions Found in Prenatal Diagnosis
Journal of Genetic Medicine
;
: 104-108, 2013.
Article
in English
| WPRIM
| ID: wpr-196055
ABSTRACT
PURPOSE:
This study was designed to confirm whether the paracentric inversions of fetuses and parents may be harmless. MATERIALS ANDMETHODS:
We report 10 cases (0.14%) with paracentric inversions among 7,181 prenatal cases observed during prenatal diagnosis performed at Cheil General Hospital between January 2009 and June 2013. We used cytogenetic GTL- and RBG-banding techniques.RESULTS:
Of the 10 cases, nine cases were transmitted from each of the parents, and one case was de novo. Nine cases were phenotypically normal up to one month of age after birth. One case was lost to follow-up. We present prenatal diagnosis and follow-up examination of the fetuses with paracentric inversion.CONCLUSION:
Based on our cases, most paracentric inversions are considered to be harmless. The precise identification of paracentric inversions might be clinically important and helpful for genetic counseling.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parents
/
Prenatal Diagnosis
/
Chorionic Villi Sampling
/
Follow-Up Studies
/
Cytogenetics
/
Parturition
/
Lost to Follow-Up
/
Fetus
/
Genetic Counseling
/
Amniocentesis
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Journal of Genetic Medicine
Year:
2013
Type:
Article
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