Long-Term Tolerability of Escitalopram in Korean Adolescents
Journal of the Korean Academy of Child and Adolescent Psychiatry
;
: 207-212, 2013.
Article
in English
| WPRIM
| ID: wpr-196062
ABSTRACT
OBJECTIVES:
We investigated the long-term tolerability of escitalopram in Korean adolescents.METHODS:
The subjects were 37 adolescents, who had been diagnosed with depressive disorder in accordance to DSM-IV. Clinical effectiveness was assessed by Clinical Global Impression-Improvement (CGI-I) scale at the final follow-up visit. Tolerability was assessed through a medical record of the reason for discontinuation of escitalopram and documented adverse events.RESULTS:
The mean duration of treatment was 78.1+/-89.5 days, and the mean dosage was 10.0+/-4.4mg/day. Out of the total 37 patients, two (5%) patients sustained use of escitalopram. Twelve patients (32.4%) discontinued use of escitalopram due to target symptom remission, and 23 patients (61.9%) due to insufficient efficacy. Six patients (16.2%) had at least one documented adverse event. However, no suicidal ideation or self-injurious behavior was reported. Significant differences in clinical symptom improvement efficacy were seen between the patients who were receiving escitalopram for less than 8 weeks (4.3%, 1/13) and those for more than 8 weeks (92.9%, 13/14). There was no significant difference between the tolerability of monotherapy compared to the concomitant use group.CONCLUSION:
The results of this study suggest that long-term use of escitalopram may result in superior efficacy than short-term use, and is tolerable in Korean adolescents with depression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Citalopram
/
Medical Records
/
Follow-Up Studies
/
Self-Injurious Behavior
/
Diagnostic and Statistical Manual of Mental Disorders
/
Depression
/
Depressive Disorder
/
Suicidal Ideation
Type of study:
Observational study
/
Prognostic study
Limits:
Adolescent
/
Humans
Language:
English
Journal:
Journal of the Korean Academy of Child and Adolescent Psychiatry
Year:
2013
Type:
Article
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