The factors associated with the efficacy of indomethacin treatment in premature infants with patent ductus arteriosus / 소아과
Korean Journal of Pediatrics
;
: 531-535, 2007.
Article
in Korean
| WPRIM
| ID: wpr-196114
ABSTRACT
PURPOSE:
Indomethacin treatment is successful in about 90% of patent ductus arteriosus (PDA) in premature infants, but in some, repeated administration or surgical closure is required. The object of the present study is to determine the factors affecting the efficacy of indomethacin treatment and to predict the treatment result.METHOD:
The 29 preterm neonates, admitted to neonatal intensive care unit of Kyunghee university medical center and Eulji university hospital between September 2002 and April 2006 were diagnosed of PDA and treated with indomethacin. The risk factors that might affect the efficacy of treatment were studied retrospectively.RESULTS:
The single-administered group was 19 patients out of 29 (65.5%) and among the repeated- administered group, 5 patients (17.2%) had repeated indomethacin administration and the other 5 patients (17.2%) underwent surgery due to reopening of the duct after repeated medical treatment. In repeated-administered group, the diameter of PDA was significantly larger (3.66+/-0.8 mm vs 2.55+/-0.8 mm, P3.5 mm) and older postnatal age (>7 days), the effect of indomethacin was decreased. Therefore in such cases, repeated dose of indomethacin or surgical ligation should be considered earlier.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Birth Weight
/
Infant, Premature
/
Intensive Care, Neonatal
/
Indomethacin
/
Retrospective Studies
/
Risk Factors
/
Sensitivity and Specificity
/
Gestational Age
/
Ductus Arteriosus
/
Ductus Arteriosus, Patent
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Infant
/
Infant, Newborn
Language:
Korean
Journal:
Korean Journal of Pediatrics
Year:
2007
Type:
Article
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