Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity
Gut and Liver
;
: 10-20, 2012.
Article
in English
| WPRIM
| ID: wpr-196160
ABSTRACT
The global obesity epidemic has resulted in significant morbidity and mortality. However, the medical treatment of obesity is limited. Gastric bypass is an effective surgical treatment but carries significant perioperative risks. The gut hormones, peptide tyrosine tyrosine (PYY) and glucagon-like peptide 1 (GLP-1), are elevated following gastric bypass and have been shown to reduce food intake. They may provide new therapeutic targets. This review article provides an overview of the central control of food intake and the role of PYY and GLP-1 in appetite control. Key translational animal and human studies are reviewed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Appetite
/
Tyrosine
/
Gastric Bypass
/
Peptide Hormones
/
Eating
/
Glucagon-Like Peptide 1
/
Obesity
Limits:
Animals
/
Humans
Language:
English
Journal:
Gut and Liver
Year:
2012
Type:
Article
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