Study on the Short-Term Hemodynamic Effects of Experimental Cardiomyoplasty in Heart Failure Model / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery
;
: 224-236, 1999.
Article
in Korean
| WPRIM
| ID: wpr-196262
ABSTRACT
BACKGROUND:
To evaluate the short-term effect of dynamic cardiomyoplasty on circulatory function and detect the related factors that can affect it, experimental cardiomyoplasties were performed under the state of normal cardiac function and heart failure. MATERIAL ANDMETHOD:
A total of 10 mongrel dogs weighing 20 to 30kg were divided arbitrarily into two groups. Five dogs of group A underwent cardiomyoplasty with latissimus dorsi(LD) muscle mobilization followed by a 2-week vascular delay and 6-week muscle training. Then, hemodynamic studies were conducted. In group B, doxorubicin was given to 5 dogs in an IV dose of 1 mg/kg once a week for 8 weeks to induce chronic heart failure, and simultaneous muscle training was given for preconditioning during this period. Then, cardiomyoplasties were performed and hemodynamic studies were conducted immediately after these cardiomyoplasties in group B.RESULT:
In group A, under the state of normal cardiac function, only mean right atrial pressure significantly increased with the pacer-on(p0.05), the larger augmentation effect seen in group B is presumed to be mainly attributed to the viability and contractility of the LD muscle.CONCLUSION:
These results indicate that the positive circulatory augmentation effect of cardiomyoplasty is apparent only under the state of heart failure and the preservation of muscle contractility is important to maximize this effect.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Capillaries
/
Cardiac Output
/
Doxorubicin
/
Ventricular Pressure
/
Cardiomyoplasty
/
Stroke
/
Atrial Pressure
/
Heart
/
Heart Failure
/
Hemodynamics
Limits:
Animals
Language:
Korean
Journal:
The Korean Journal of Thoracic and Cardiovascular Surgery
Year:
1999
Type:
Article
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