Diagnostic Significance of Anti-CCP Antibody in Korean Early Rheumatoid Arthritis / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 227-234, 2007.
Article
in Korean
| WPRIM
| ID: wpr-196281
ABSTRACT
OBJECTIVE:
To identify the sensitivity and specificity of the anti-cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor (RF) in a diagnosis of Korean early rheumatoid arthritis (RA).METHODS:
Two hundred and sixty two patients diagnosed with RA were examined retrospectively and classified by three groups. A group 1 had a disease duration24 months, and the third was a group of total patients. The sensitivity and specificity of the RF and anti-CCP in each group of RA were identified. Patients of the connective tissue disease other than rheumatoid arthritis were tested with RF and anti-CCP.RESULTS:
The sensitivity/specificity of RF and the anti-CCP in early RA were 90.4%/68.0% and 87.5%/89.3%, 91.3%/68.0%, 81.7%/89.3% in each, and 90.4%/68.0% and 84.7%/89.3% in the total RA patients. The accurate diagnosis rate, which is defined as (number of true positives plus true negatives)/ the total number of patients), of the RF and anti-CCP was 79.2%/88.4% in the early RA group, and 79.4% and 89.0% in the total patients group.CONCLUSION:
Anti-CCP is more specific than RF in diagnosing RA. Although it is not statistically significant, diagnositc sensitivity of anti-CCP in early RA group is higher than that of established RA group.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis, Rheumatoid
/
Rheumatoid Factor
/
Retrospective Studies
/
Sensitivity and Specificity
/
Connective Tissue Diseases
/
Diagnosis
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
The Journal of the Korean Rheumatism Association
Year:
2007
Type:
Article
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