Ubiquitination of Aquaporin: in the kidney
Electrolytes & Blood Pressure
;
: 1-4, 2009.
Article
in English
| WPRIM
| ID: wpr-196692
ABSTRACT
Ubiquitination is known to be important for endocytosis and lysosomal degradation of aquaporin-2 (AQP2). Ubiquitin (Ub) is covalently attached to the lysine residue of the substrate proteins and activation and attachment of Ub to a target protein is mediated by the action of three enzymes (i.e., E1, E2, and E3). In particular, E3 Ub-protein ligases are known to have substrate specificity. This minireview will discuss the ubiquitination of AQP2 and identification of potential E3 Ub-protein ligases for 1-deamino-8-D-arginine vasopressin (dDAVP)-dependent AQP2 regulation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Substrate Specificity
/
Vasopressins
/
Proteins
/
Ubiquitin
/
Deamino Arginine Vasopressin
/
Endocytosis
/
Aquaporin 2
/
Ubiquitination
/
Kidney
/
Kidney Tubules, Collecting
Language:
English
Journal:
Electrolytes & Blood Pressure
Year:
2009
Type:
Article
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