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Evaluation of the periodontal regenerative properties of patterned human periodontal ligament stem cell sheets
Journal of Periodontal & Implant Science ; : 402-415, 2017.
Article in English | WPRIM | ID: wpr-196790
ABSTRACT

PURPOSE:

The aim of this study was to determine the effects of patterned human periodontal ligament stem cell (hPDLSC) sheets fabricated using a thermoresponsive substratum.

METHODS:

In this study, we fabricated patterned hPDLSC sheets using nanotopographical cues to modulate the alignment of the cell sheet.

RESULTS:

The hPDLSCs showed rapid monolayer formation on various surface pattern widths. Compared to cell sheets grown on flat surfaces, there were no significant differences in cell attachment and growth on the nanopatterned substratum. However, the patterned hPDLSC sheets showed higher periodontal ligamentogenesis-related gene expression in early stages than the unpatterned cell sheets.

CONCLUSIONS:

This experiment confirmed that patterned cell sheets provide flexibility in designing hPDLSC sheets, and that these stem cell sheets may be candidates for application in periodontal regenerative therapy.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Periodontal Ligament / Regeneration / Stem Cells / Gene Expression / Pliability / Cues / Tissue Engineering / Extracellular Matrix Limits: Humans Language: English Journal: Journal of Periodontal & Implant Science Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Periodontal Ligament / Regeneration / Stem Cells / Gene Expression / Pliability / Cues / Tissue Engineering / Extracellular Matrix Limits: Humans Language: English Journal: Journal of Periodontal & Implant Science Year: 2017 Type: Article