SoxD Transcription Factors: Multifaceted Players of Neural Development
International Journal of Stem Cells
;
: 3-8, 2016.
Article
in English
| WPRIM
| ID: wpr-196828
ABSTRACT
SoxD transcription factor subfamily includes three members, Sox5, Sox6, and Sox13. Like other Sox genes, they contain the High-Mobility-Group (HMG) box as the DNA binding domain but in addition feature the subgroup-specific leucine zipper motif. SoxD genes are expressed in diverse cell types in multiple organs during embryogenesis and in adulthood. Among the cells expressing them are those present in the developing nervous system including neural stem (or progenitor) cells as well as differentiating neurons and oligodendrocytes. SoxD transcription factors do not contain distinct activator or repressor domain, and they are believed to function in modulation of other transcription factors in promoter- specific manners. This brief review article will attempt to summarize the latest studies on the function of SoxD genes in embryogenesis with a particular emphasis on the regulation of neural development.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transcription Factors
/
DNA
/
Oligodendroglia
/
Leucine Zippers
/
Embryonic Development
/
SOXD Transcription Factors
/
Neural Stem Cells
/
Nervous System
/
Neurons
Limits:
Pregnancy
Language:
English
Journal:
International Journal of Stem Cells
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS