Enhancement of skin permeation of vitamin C using vibrating microneedles
Translational and Clinical Pharmacology
;
: 15-20, 2017.
Article
in English
| WPRIM
| ID: wpr-196852
ABSTRACT
This study was performed to evaluate the use of vibrating microneedles for the transdermal delivery of vitamin C. The microneedles were designed to vibrate at three levels of intensity. In vitro permeation by vitamin C was evaluated according to the specific conditions such as vibration intensity (levels 1, 2 and 3), application time (1, 3, 5, 7 and 10 min), and application power (500, 700 and 1,000 g). The highest permeation of vitamin C was observed at level 3 of vibration intensity, 5 min of application, and 1,000 g of application power. Vitamin C gel showed no cytotoxic effect against Pam212 cells or skin irritation effects. A pharmacokinetic study of the gel in rats was conducted under optimized conditions. The AUC₀-∞ and C(max) increased 1.35-fold and 1.44-fold, respectively, compared with those after vitamin C gel without application with vibrating microneedles. The present study suggests that vibrating microneedles can be used to facilitate the skin permeability of vitamin C under optimal conditions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Permeability
/
Ascorbic Acid
/
Skin
/
Vibration
/
Vitamins
/
In Vitro Techniques
/
Pharmacokinetics
Limits:
Animals
Language:
English
Journal:
Translational and Clinical Pharmacology
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS