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The Effect of Electrical Field Stimulation and alpha-Adrenergic Agonist on the Contraction of Vas Deferens after Vasectomy in the Rat / 대한비뇨기과학회지
Korean Journal of Urology ; : 1151-1158, 1997.
Article in Korean | WPRIM | ID: wpr-197029
ABSTRACT
This study was designed to determine the effect of electrical field stimulation (EFS) and adrenergic agonist on the contractility of vasectomized prostatic and epididymal segments at postvasectomized 2, 5 and 10 weeks, and to observe innervation changes of the vas deferens after vasectomy. The contractile response was recorded on a polygraph via force transducer and expressed as the g tension per 100 mg tissue. And we reviewed histopathologic sections stained with S-100 protein by light microscopy. The results were as follows 1. In control groups, contractile responses of prostatic and epididymal segments to EFS (4, 8, 16, 32 &64 Hz) were gradually increased by increasing frequencies. But contractile responses of vasectomized epididymal segments to all frequencies of EFS declined. Contractile responses of vasectomized prostatic segments were significantly greater than that of vasectomized epididymal segments (p<0.05). 2. Contractile responses of epididymal segments to phenylephrine hydrochloride 0.00001M were significantly greater than that of prostatic segments (p<0.05). Contractile responses of prostatic segments were tend to decline. In epididymal segments, contractile response of post-vasectomized 5 weeks group was significantly greater than that of control and post-vasectomized 2 weeks groups (p<0.05). 3. In control and vasectomized prostatic segment, nerve bundles were strongly positive and intact histopathologically for the S-100 protein immunohistochemical stain. In epididymal segment, nerve bundles were intact in control group. However, vacuolar degeneration tend to be gradually increased and stained weakly by increasing duration in vasectomized epididymal segment. These results suggest that the progression of degenerative change of adrenergic innervation after vasectomy may play an important role in progressively decreasing contractility of the vas deferens after vasectomy.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenylephrine / Transducers / Vas Deferens / Vasectomy / S100 Proteins / Adrenergic alpha-Agonists / Adrenergic Agonists / Microscopy Limits: Animals Language: Korean Journal: Korean Journal of Urology Year: 1997 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenylephrine / Transducers / Vas Deferens / Vasectomy / S100 Proteins / Adrenergic alpha-Agonists / Adrenergic Agonists / Microscopy Limits: Animals Language: Korean Journal: Korean Journal of Urology Year: 1997 Type: Article