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Cytomegalovirus Retinitis after Intravitreal Bevacizumab Injection in an Immunocompetent Patient
Korean Journal of Ophthalmology ; : 61-63, 2013.
Article in English | WPRIM | ID: wpr-19703
ABSTRACT
We report a case of cytomegalovirus (CMV) retinitis after intravitreal bevacizumab injection. A 61-year-old woman with diabetic macular edema developed dense vitritis and necrotizing retinitis 3 weeks after intravitreal bevacizumab injection. A diagnostic vitrectomy was performed. The undiluted vitreous sample acquired by vitrectomy was analyzed by polymerase chain reaction and culture. Polymerase chain reaction of the vitreous was positive for CMV DNA. Other laboratory results did not show evidence of other infectious retinitis and systemic immune dysfunction. Human immunodeficiency virus antibodies were also negative. After systemic administration of ganciclovir, retinitis has resolved and there has been no recurrence of retinitis during the follow-up period of 12 months. Ophthalmologists should be aware of potential risk for CMV retinitis after intravitreal bevacizumab injection.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: DNA, Viral / Macular Edema / Polymerase Chain Reaction / Cytomegalovirus Retinitis / Angiogenesis Inhibitors / Cytomegalovirus / Vascular Endothelial Growth Factor A / Diagnosis, Differential / Intravitreal Injections / Antibodies, Monoclonal, Humanized Type of study: Diagnostic study Limits: Female / Humans Language: English Journal: Korean Journal of Ophthalmology Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: DNA, Viral / Macular Edema / Polymerase Chain Reaction / Cytomegalovirus Retinitis / Angiogenesis Inhibitors / Cytomegalovirus / Vascular Endothelial Growth Factor A / Diagnosis, Differential / Intravitreal Injections / Antibodies, Monoclonal, Humanized Type of study: Diagnostic study Limits: Female / Humans Language: English Journal: Korean Journal of Ophthalmology Year: 2013 Type: Article