A case of TSH-secreting pituitary adenoma with acromegaly / 대한내과학회지
Korean Journal of Medicine
;
: S97-S102, 2009.
Article
in Korean
| WPRIM
| ID: wpr-197363
ABSTRACT
Growth hormone (GH) and thyrotropin (TSH)-secreting pituitary adenomas are very rare and account for only 0.5% of all pituitary adenomas. We report a case of a GH/TSH-secreting pituitary adenoma in a 53-year-old male patient. He presented with symptoms of thyrotoxicosis, clinical features of acromegaly, and diabetes mellitus. The laboratory examinations showed high serum levels of free T4, TSH, and free alpha-subunit. Additionally, serum levels of GH and insulin-like growth factor (IGF-1) wereincreased. GH was not suppressed below 1 microgram/L by an oral 75 g glucose loading test, and TSH was not stimulated by thyrotropin- releasing hormone. A sellar MRI showed a large lobulated mass on the pituitary gland, so transcranial surgery was performed. Immunohistochemical staining showed anti-GH and anti-TSH positive tumor cells in the cytoplasm. Serum GH, IGF-1, free T4, and TSH levels normalized after surgery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pituitary Gland
/
Pituitary Neoplasms
/
Acromegaly
/
Thyrotoxicosis
/
Insulin-Like Growth Factor I
/
Growth Hormone
/
Thyrotropin
/
Cytoplasm
/
Diabetes Mellitus
/
Thyrotrophs
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2009
Type:
Article
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