The Relationship between the p27 Expression of Papillary Thyroid Cancer Cells Obtained by FNA and Cervical Lymph Node Metastasis / 대한내분비외과학회지
Korean Journal of Endocrine Surgery
;
: 155-160, 2009.
Article
in Korean
| WPRIM
| ID: wpr-19737
ABSTRACT
PURPOSE:
The p27 gene as a tumor suppressor gene is associated with colorectal cancer, gastric cancer and breast cancer. Some studies have shown a relationship between the underexpression of p27 and lymph node metastasis in papillary thyroid carcinoma. The aim of this study is to evaluate the relationship between a p27 expression of the papillary thyroid cancer cells obtained by fine needle aspiration (FNA) and cervical lymph node metastasis.METHODS:
This study included 60 patients with papillary thyroid cancer and who underwent total thyroidectomy or lobectomy. Central lymph node dissection was routinely done. Out of these patients, 30 patients underwent a FNA procedure during the operation. Immunohistochemical staining for p27 antibody was performed on the papillary thyroid cancer tissues and cells.RESULTS:
Cervical lymph node metastasis is correlated with the tumor size and lymphovascular invasion (P<0.001). The underexpression of p27 for the papillary thyroid cancer tissues and cells was associated with lymph node metastasis (P=0.009).CONCLUSION:
An evaluation of the p27 expression for the papillary thyroid cancer cells obtained by FNA may be useful as a predictor for lymph node metastasis before surgery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stomach Neoplasms
/
Thyroid Gland
/
Thyroidectomy
/
Breast Neoplasms
/
Thyroid Neoplasms
/
Colorectal Neoplasms
/
Genes, Tumor Suppressor
/
Biopsy, Fine-Needle
/
Lymph Node Excision
/
Lymph Nodes
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Endocrine Surgery
Year:
2009
Type:
Article
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