The Effect of Lipo-PGE1 on the Viability of Injected Adipose Tissue on Mouse Model
Journal of the Korean Society of Plastic and Reconstructive Surgeons
;
: 526-530, 2010.
Article
in Korean
| WPRIM
| ID: wpr-197400
ABSTRACT
PURPOSE:
With the recent recognition of the importance of soft-tissue fillers, fat grafting has been assumed an increasingly important role as both an adjunctive and a primary procedure in aesthetic and reconstructive surgery. The main problem in achieving long-term soft-tissue augmentation is partial absorption of the injected fat and hence the need for overcorrection and re-injection. The purpose of this study is to improve the viability of the injected fat by the use of Lipo-PGE1.METHODS:
Human adipose tissue, obtained by suction-assisted lipectomy, was re-injected into the subcutaneous layer in the scalp of ICR mice. Lipo-PGE1 (0.5 microgram/kg) was injected intravenously in experimental group for 7 days from the operation day and saline was injected in control group. There were 5 animals in each group. The animals were euthanized 4 weeks after the procedure. Graft weight and volume were measured and histologic evaluation was performed.RESULTS:
Histologic analysis demonstrated significantly less cyst formation and less inflammatory reaction in the group treated with Lipo-PGE1. No significant difference was found between the groups regarding graft volume or the other histologic parameters investigated. Significant differences were demonstrated in microvascular density count.CONCLUSION:
Less cyst formation, less inflammation, more angiogenesis indicating improved quality of the injected fat can be obtained by the addition of Lipo-PGE1. Further studies of various dosages of Lipo-PGE1 and their long-term effect are required before these encouraging results could be applied clinically.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Scalp
/
Alprostadil
/
Lipectomy
/
Adipose Tissue
/
Survival Rate
/
Transplants
/
Absorption
/
Inflammation
/
Mice, Inbred ICR
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Plastic and Reconstructive Surgeons
Year:
2010
Type:
Article
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