Clinical Characteristics in Herpes Simplex Virus 2 Meningitis in a Retrospective Single Center Study
Journal of the Korean Neurological Association
;
: 112-115, 2016.
Article
in Korean
| WPRIM
| ID: wpr-197552
ABSTRACT
BACKGROUND:
Herpes simplex virus type 2 (HSV-2) is the second most common cause of viral meningitis and the most common cause of recurrent meningitis. Although the incidence of HSV-2 meningitis is high, its clinical characteristics are not well known. The purpose of this study was to review the clinical characteristics and prognosis of HSV-2 meningitis.METHODS:
We analyzed patients who were admitted to the Department of Neurology at Severance Hospital with a final diagnosis of HSV-2 meningitis, as confirmed by applying the polymerase chain reaction to the cerebrospinal fluid (CSF) of patients.RESULTS:
The study involved 998 patients with aseptic meningitis and 60 patients diagnosed with HSV-2 meningitis. The mean age at meningitis presentation was 32.5 years (range 18-54 years), and 72% of the patients were female. Common clinical symptoms were headache (100%), nausea and/or vomiting (83%), meningismus (57%), and fever (55%). Six patients had a history of genital herpes infection, and 11 had a past history of recurrent meningitis. The CSF study was notable for elevated protein (111.0±53.5 mg/dL, mean±standard deviation) and white cell count (332.0±211.3 cells/µL). The CSF/serum glucose ratio was 0.52±0.90. Various treatments were applied, including conservative care, antiviral agents, empirical antibiotics, and combined treatments. All patients recovered without serious neurologic sequelae.CONCLUSIONS:
HSV-2 meningitis is relatively common, as are recurrent episodes. The clinical characteristics of HSV-2 meningitis are similar to those of other types of aseptic meningitis. HSV-2 meningitis is treated using antiviral therapy, and the prognosis is favorable even with conservative treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Prognosis
/
Vomiting
/
Herpes Genitalis
/
Cell Count
/
Cerebrospinal Fluid
/
Polymerase Chain Reaction
/
Incidence
/
Retrospective Studies
/
Simplexvirus
Type of study:
Diagnostic study
/
Incidence study
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
2016
Type:
Article
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