Correlation of EGFR and c-erbB-2 Gene Amplifications and Expression of COX-2 Protein in Invasive Ductal Carcinomas of the Breast
Journal of the Korean Surgical Society
;
: 279-285, 2005.
Article
in Korean
| WPRIM
| ID: wpr-197782
ABSTRACT
PURPOSE:
Abnormalities of epidermal growth factor receptor (EGFR) and c-erbB-2 have been actively investigated in breast cancer. Cyclooxygenase-2 (COX-2) seems to be involved in critical steps of cancer onset and progression. The purpose of this study is to determine the correlation between the gene ampilfications of the EGFR and c-erbB-2 and expression of the COX-2.METHODS:
Using Chromogenic in situ Hybridization (CISH) the gene amplification of the EGFR and c-erbB-2 were studies on paraffin sections of 47 invasive ductal carcinomas. The expression of COX-2 was studied immunohistochemically (IHC).RESULTS:
Of the 47 invasive duct carcinomas, gene amplifications of the EGFR and c-erbB-2 by CISH were observed in 21 cases (44.7%) and 14 cases (29.8%), respectively. The gene amplification of EGFR was significantly correlated with tumor size, nodal metastasis, and stage. The gene amplification of c-erbB-2 showed a statistically significant correlation with tumor size and stage. The protein of COX-2 was expressed by IHC in 30 cases (63.8%). The expression of the COX-2 protein showed a statistically significant correlation with tumor size, nodal metastasis, and stage. The gene amplifications of the EGFR and c-erbB-2 between expression of COX-2 protein showed a statistically significant correlation.CONCLUSION:
The gene amplification of the EGFR and c- erbB-2 may be correlated with expression of COX-2 protein in the breast cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraffin
/
Breast
/
Breast Neoplasms
/
Gene Amplification
/
In Situ Hybridization
/
Genes, erbB-2
/
Carcinoma, Ductal
/
Cyclooxygenase 2
/
ErbB Receptors
/
Neoplasm Metastasis
Language:
Korean
Journal:
Journal of the Korean Surgical Society
Year:
2005
Type:
Article
Similar
MEDLINE
...
LILACS
LIS