The Usefulness of Serum Total IgE Test by Multiple Allergosorbent Test-Chemiluminescent Assay(MAST-CLA): Comparison with Paper Radioimmunosorbent Test(PRIST)
Journal of the Korean Pediatric Society
;
: 397-402, 1999.
Article
in Korean
| WPRIM
| ID: wpr-197877
ABSTRACT
PURPOSE:
Multiple allergosorbent test-chemiluminescent assay(MAST-CLA) is a semiquantitative method for detecting total IgE and specific IgE in serum. The purposes of this study are to investigate the correlation between MAST-CLA and Paper radioimmunosorbent test(PRIST), and to find out whether MAST-CLA can replace PRIST in measuring of serum total IgE.METHODS:
Data of 162 subjects were analyzed by linear regression analysis for MAST-CLA (MAST class) and PRIST(PRIST IgE, PRIST class, PRIST log10 IgE). Diagnostic sensitivity, specificity, efficiency, positive and negative predictive values were calculated by standard methods.RESULTS:
The sensitivity of MAST-CLA was 64.0%, specificity was 56.0%, efficiency was 56.0%, positive predictive value was 87.2% and negative predictive value was 21.8%. The overall correlation coefficiency(r) of total IgE between MAST class vs PRIST IgE was 0.176(P<0.05), MAST class vs PRIST class was 0.308(P<0.001), MAST class vs PRIST log10 IgE was 0.301(P<0.001). According to age classification, good correlation was obtained in the 3-6 yr age group(MAST class vs PRIST IgE r=0.283, P<0.01, MAST class vs PRIST log10 IgE r=0.377, P<0.001), but there were no significant correlation in the 7-10 yr age group and in the 11-15 yr age group.CONCLUSION:
A different correlation was observed between the two tests according to age, so we suggest that simultaneous use of PRIST should be performed considering the age when MAST-CLA is used as an atopy screening.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunoglobulin E
/
Linear Models
/
Mass Screening
/
Sensitivity and Specificity
/
Classification
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Pediatric Society
Year:
1999
Type:
Article
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