Reduction of Continuous Theta Burst Stimulation-Induced Motor Plasticity in Healthy Elderly With COMT Val158Met Polymorphism
Annals of Rehabilitation Medicine
;
: 658-664, 2014.
Article
in English
| WPRIM
| ID: wpr-198069
ABSTRACT
OBJECTIVE:
To delineate whether cortical plasticity induced by continuous theta burst stimulation (cTBS) differed according to catechol-O-methyltransferase (COMT) gene polymorphism in healthy older adults.METHODS:
Eighteen healthy older volunteers (mean age 73.78+/-5.04; 12 females and 6 males) were recruited. Volunteers randomly assigned in either a sham-first or real cTBS first group participated in two separate TMS visits with at least a 2-day wash-out period. Genotyping was carried out at baseline by a separate researcher who was blinded. cTBS was delivered in a hot spot over M1 at an active motor threshold of 80%. Motor evoked potentials (MEPs) were obtained at 120% of the resting motor threshold before and after sham/cTBS.RESULTS:
The relative MEP to baseline was significantly decreased 0 and 10 minutes post-stimulation and increased 40 minutes post-stimulation, as compared with the sham condition. Immediately after cTBS, the Val/Val group had a significantly reduced relative MEP value, as compared with the MET carrier group.CONCLUSION:
In healthy older persons, cTBS-induced motor plasticity was reduced in the COMT Val/Val group as compared with the 158Met carrier group.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plastics
/
Polymorphism, Genetic
/
Volunteers
/
Catechol O-Methyltransferase
/
Evoked Potentials, Motor
/
Transcranial Magnetic Stimulation
/
Motor Cortex
/
Neuronal Plasticity
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
English
Journal:
Annals of Rehabilitation Medicine
Year:
2014
Type:
Article
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