Reversal of Apparent Diffusion Coefficient (ADC) Following Transient Focal Cerebral Ischemia in Cats
Journal of the Korean Radiological Society
;
: 293-300, 2002.
Article
in Korean
| WPRIM
| ID: wpr-198184
ABSTRACT
PURPOSE:
To determine the minimal threshold ADC ratio suggesting reversible ischemia in a temporary model of MCAO. MATERIALS ANDMETHODS:
Seven Korean cats weighing 3-3.5 kg were used as a temporary model of MCAO. The MCA was occluded for 1 hour, and diffusion-weighted images (DWI), and ADC and regional cerebral blood volume (rCBV) maps, were obtained at 1, 3, 6 and 24 hours after reperfusion using a 1.5T MR unit. The Cats were sacrificed 24 hours after imaging. Triphenyl tetrazolium chloride (TTC) staining of brain slices was performed, and DWI images and TTC-stained brain slices were compared with the naked eye. Reversible ischemia was defined as the area of high signal intensity at 1-hour DWI that normalized at follow-up DWI and in which TTC staining was normal. Using the ADC image obtained at 1 hour after reperfusion, 60 ADC ratios were obtained in the periphery of the infarct and reversible ischemia. Tissue survival showing normal TTC staining was used for final determination. The sensitivity and specificity of each ADC ratio was obtained and an ROC curve was plotted.RESULTS:
Five of seven cats showed the reversible ischemia. An area of high signal intensity was seen on DWI images obtained 1 hour after reperfusion, and this improved at follow-up imaging. The distribution of the ADC ratio in the periphery of the infarct core was 0.71-0.81, and in the periphery of reversible ischemia it was 0.79-0.93. The ADC ratio of 0.80 obtained 1 hr after reperfusion predicted the survival of the ischemic tissue with 93% sensitivity and 90% specificity. The ADC ratio of the reversible ischemia was 0.82+/-0.03 at 1 hour after reperfusion, and this was higher than that of the infarct, which was 0.74+/-0.03.CONCLUSION:
The minimal threshold ADC ratio suggesting reversible ischemia in this temporary model of MCAO was 0.80.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tissue Survival
/
Blood Volume
/
Brain
/
Reperfusion
/
Brain Ischemia
/
ROC Curve
/
Follow-Up Studies
/
Sensitivity and Specificity
/
Diffusion
/
Ischemia
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Radiological Society
Year:
2002
Type:
Article
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