Barrett's Esophagus: Diagnosis, Screening, Surveillance, and Controversies
Gut and Liver
;
: 93-100, 2007.
Article
in English
| WPRIM
| ID: wpr-198229
ABSTRACT
Barrett's esophagus (BE) is a frequent complication of gastroesophageal reflux disease, an acquired condition resulting from persistent mucosal injury to the esophagus. The incidence of Barrett's metaplasia and Barrett's adenocarcinoma has been increasing, but the prognosis of Barrett's adenocarcinoma is worse because individuals present at a late stage. Attempts have been made to intervene at early stage using surveillance programmes, although proof of efficacy of endoscopic surveillance is lacking. There is much to be learned about BE. Whether adequate control of gastroesophageal reflux early in the disease alters the natural history of Barrett's change once it has developed remains unanswered. Thus there is great need for carefully designed large randomised controlled trials to address these issues in order to determine how best to manage patients with BE. The AspECT and BOSS clinical trials proride this basis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Barrett Esophagus
/
Adenocarcinoma
/
Gastroesophageal Reflux
/
Mass Screening
/
Incidence
/
Natural History
/
Diagnosis
/
Esophagus
/
Metaplasia
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Incidence study
/
Prognostic study
/
Screening study
Limits:
Humans
Language:
English
Journal:
Gut and Liver
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS