TNF-alpha concentration of plasma and peritoneal fluid in women with endometriosis: Dose TNF-alpha influence the pathogenesis of endometriosis / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
; : 1617-1620, 2001.
Article
in Ko
| WPRIM
| ID: wpr-198327
Responsible library:
WPRO
ABSTRACT
OBJECTIVE: Our purpose of study was to investigate whether in vivo levels of tumor necrosis factor-alpha in plasma and peritoneal fluid (PF) differ in women with and without endometriosis.Design : Prospective and case-control study. METHODS: Fifty-seven women with laparotomy or laparoscopic findings of minimal to severe endometriosis, and forty-two women with no visual evidence of pelvic endometriosis and with benign gynecologic disease. Tumor necrosis factor-alpha levels in plasma and PF were determined using commercial ELISA. Tumor necrosis factor-alpha concentrations were compared among women with and without endometriosis, and then also were compared according to the revised American Fertility Society classification. RESULTS: Tumor necrosis factor-alpha concentrations were not significantly increased in the plasma and PF of women with endometriosis than in matched normal controls. Tumor necrosis factor-alpha concentrations in endometriosis stage III and IV were sightly increased, which were not increased statistically significant. CONCLUSIONS: Plasma and PF tumor necrosis factor-alpha levels were not different between women with and without endometriosis. Our RESULTS: do not rule out the hypothesis that tumor necrosis factor-alpha may be involved in the pathogenesis of some features of endometriosis.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Plasma
/
Ascitic Fluid
/
Enzyme-Linked Immunosorbent Assay
/
Case-Control Studies
/
Prospective Studies
/
Tumor Necrosis Factor-alpha
/
Classification
/
Endometriosis
/
Fertility
/
Genital Diseases, Female
Type of study:
Etiology_studies
/
Observational_studies
Limits:
Female
/
Humans
Language:
Ko
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2001
Type:
Article