Prognostic Factors for Patients with Bone-Only Metastasis in Breast Cancer
Yonsei Medical Journal
;
: 1168-1177, 2013.
Article
in English
| WPRIM
| ID: wpr-198359
ABSTRACT
PURPOSE:
Bone is the most frequent site of metastasis among breast cancer patients. We investigated prognostic factors affecting survival following bone-only metastasis in breast cancer patients. MATERIALS ANDMETHODS:
The medical records of breast cancer patients who were treated and followed at Gangnam Severance Hospital retrospectively reviewed to identify patients with bone-only metastasis.RESULTS:
The median time from the diagnosis of bone-only metastasis to the last follow-up or death was 55.2 [95% confidence interval (CI), 38.6-71.9] months. The Kaplan-Meier overall survival estimate at 10 years for all patients was 34.9%. In the multivariate Cox regression model, bisphosphonate treatment [hazard ratio=0.18; 95% CI, 0.07-0.43], estrogen receptor positivity (hazard ratio=0.51; 95% CI, 0.28-0.94), and solitary bone metastasis (hazard ratio=0.32; 95% CI, 0.14-0.72) were significantly associated with longer overall survival in the bone-only recurrence group. Among the treatment modalities, only bisphosphonate treatment was identified as a significant prognostic factor.CONCLUSION:
Identifying the factors influencing breast cancer mortality after bone-only metastasis will help clarify the clinical course and improve the treatment outcome for patients with breast cancer and bone-only metastasis. Bisphosphonates, as a significant prognostic factor, warrant further investigation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Bone Neoplasms
/
Breast Neoplasms
/
Receptors, Progesterone
/
Receptors, Estrogen
/
Survival Analysis
/
Multivariate Analysis
/
Regression Analysis
/
Retrospective Studies
/
Antineoplastic Agents
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Yonsei Medical Journal
Year:
2013
Type:
Article
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