Elevated serum immunoglobulin E level as a marker for progression of immunoglobulin A nephropathy
Kidney Research and Clinical Practice
;
: 147-151, 2016.
Article
in English
| WPRIM
| ID: wpr-198731
ABSTRACT
BACKGROUND:
Immunoglobulin E (IgE) has traditionally been associated with anaphylaxis and atopic disease. Previous studies reported that serum IgE levels are elevated in nephrotic syndrome and suggested IgE levels as a prognostic indicator in glomerular diseases. The aim of this study was to explore the association between serum IgE levels and renal outcome in patients with immunoglobulin A nephropathy (IgAN).METHODS:
We included 117 patients with biopsy-proven IgAN. Renal progression was defined if a patient meets one of these criteria (1) a negative value of delta estimated glomerular filtration rate (mL/min/1.73 m²/mo) or (2) a rise in serum creatinine to an absolute level of ≥ 1.3 mg/dL (male) or 1.2 mg/dL (female). We defined delta changes in serum creatinine, estimated glomerular filtration rate, and proteinuria as a difference of values during the follow-up period.RESULTS:
A total of 117 patients with IgAN were included. The serum IgE level was significantly high in the renal progressive group compared with the nonprogressive group. Sex and history of gross hematuria were significantly different between the high-IgE group and the low-IgE group. Regression analysis showed that a male sex, initial proteinuria, and change of proteinuria were significantly associated with serum IgE levels.CONCLUSION:
The serum IgE level is potentially associated with disease progression and pathogenesis of IgAN.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Proteinuria
/
Immunoglobulin A
/
Immunoglobulin E
/
Immunoglobulins
/
Follow-Up Studies
/
Disease Progression
/
Creatinine
/
Glomerular Filtration Rate
/
Glomerulonephritis
/
Glomerulonephritis, IGA
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
/
Male
Language:
English
Journal:
Kidney Research and Clinical Practice
Year:
2016
Type:
Article
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