Treatment of Intravenous Immune-Globulin Resistant Kawasaki Disease with Corticosteroids
Journal of the Korean Pediatric Society
;
: 1453-1457, 1997.
Article
in Korean
| WPRIM
| ID: wpr-198908
ABSTRACT
PURPOSE:
To evaluate the efficacy of steroid therapy on prevention of development and progression of coronary artery aneurysm in intravenous immune globulin (IVIG)-resistant Kawasaki disease, we treated three children with high dose of intravenous methylprednisolone followed by low dose oral prednisolone.METHODS:
We selected three children with Kawasaki disease who did not repond or who initially responded but soon developed recrudescent fever after retreatment of IVIG (total 4gm/kg). These three patients were treated with high dose methylprednisolone (10mg/kg) intravenously and followed by low dose prednisolone (1mg/kg) orally for 7 days. Echocardiographic evalutions were performed within 8 days of admission (before steroid therapy), at discharge and 1 month after discharge.RESULTS:
All three patients showed rapid normalization of clinical symptoms and did not developed significant coronry artery abnormalities. No adverse reaction was observed.CONCLUSIONS:
Steroid therapy (mini pulse methylprednisolone and prednisolone therapy) is valuable for patients with Kawasaki disease resistant to intravenous immune globulin therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arteries
/
Methylprednisolone
/
Prednisolone
/
Echocardiography
/
Immunoglobulins, Intravenous
/
Adrenal Cortex Hormones
/
Retreatment
/
Coronary Vessels
/
Fever
/
Aneurysm
Limits:
Child
/
Humans
Language:
Korean
Journal:
Journal of the Korean Pediatric Society
Year:
1997
Type:
Article
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