The Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in the Treatment of Brain Abscess
Journal of Korean Neurosurgical Society
;
: 278-283, 2011.
Article
in English
| WPRIM
| ID: wpr-199086
ABSTRACT
OBJECTIVE:
The purpose of this study was to evaluate whether 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) can be used to assess the therapeutic response of brain abscess.METHODS:
A study was conducted on 10 consecutive patients with brain abscess. Magnetic resonance imaging (MRI) with diffuse-weighted imaging (DWI) was performed at 3 and 6 weeks after surgical treatment and intravenous antibiotics therapy and FDG-PET at 6 weeks after treatment. The extent of the abscess, signal changes on MRI, and FDG-PET standardized uptake values were analyzed and correlated with the response to therapy.RESULTS:
Aspiration or craniotomy with excision of the abscess followed by intravenous antibiotics for 6-8 weeks resulted in good recovery with no recurrence. In 10 patients, two had low signal intensity on the DWI; one had no uptake on FDG-PET imaging after 6 weeks antibiotics and discontinued intravenous treatment, but the other patient had diffuse, increased uptake on FDG-PET imaging after 6 weeks antibiotics and underwent an additional 2 weeks of intravenous antibiotics. The remaining eight patients had high signals on the DWI. Four had no uptake on FDG-PET imaging and the treatment period varied from 6 to 8 weeks (mean, 6.75 weeks). Among the other four patients, FDG was accumulated in a diffuse or local area corresponding to a high signal area within the DWI and 2 weeks of intravenous antibiotics was added.CONCLUSION:
MRI plus FDG-PET improved the accuracy of assessing therapeutic responses to antibiotics treatment of brain abscess and aided in optimizing therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Brain
/
Brain Abscess
/
Magnetic Resonance Imaging
/
Craniotomy
/
Positron-Emission Tomography
/
Abscess
/
Electrons
/
Anti-Bacterial Agents
Limits:
Humans
Language:
English
Journal:
Journal of Korean Neurosurgical Society
Year:
2011
Type:
Article
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