Renal Biopsy Findings of Prospective Kidney Donors and Clinical Course of Renal Allografts / 대한이식학회지
The Journal of the Korean Society for Transplantation
;
: 69-74, 2007.
Article
in Korean
| WPRIM
| ID: wpr-199125
ABSTRACT
PURPOSE:
To evaluate the pathology of prospective kidney donors and assess the clinical outcomes of the renal allografts.METHODS:
We reviewed the records of 12 prospective kidney donors who underwent kidney biopsy. The indications of kidney biopsy were asymptomatic microscopic hematuria (n=88, 66.7%), decreased glomerular filtration rate (GFR, n=22, 16.7%), mild proteinuria (n=11, 8.3%), history of gross hematuria (n=11, 8.3%).RESULTS:
Kidney biopsy in 8 prospective donors with asymptomatic microscopic hematuria showed 5 (62.5%) thin basement membrane disease (TBMD); 1 IgA nephropathy; 1 Alport's syndrome; 1 mild mesangial widening. Two prospective donors with decreased GFR showed IgA nephropathy and tubulointerstitial lesion. The one with mild proteinuria showed arterionephrosclerosis and the one with a history of gross hematuria showed tubulointerstitial lesion. 4 (33.3%) of the 12 who underwent kidney biopsy were accepted as kidney donors.; 3 donors with TBMD and the donor with mild mesangial widening, who all had microscopic hematuria. Among the 4 donations, there was 1 graft failure and 3 allografts (1 mild mesangial widening, 2 TBMD) have maintained graft function at latest follow up.CONCLUSION:
The most common cause of asymptomatic microscopic hematuria in prospective kidney donors was TBMD. Long-term follow up is needed to assess the clinical outcomes of these allografts.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Proteinuria
/
Tissue Donors
/
Basement Membrane
/
Biopsy
/
Prospective Studies
/
Follow-Up Studies
/
Transplants
/
Allografts
/
Glomerular Filtration Rate
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
The Journal of the Korean Society for Transplantation
Year:
2007
Type:
Article
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