Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study
Archives of Craniofacial Surgery
;
: 9-15, 2017.
Article
in English
| WPRIM
| ID: wpr-199182
ABSTRACT
BACKGROUND:
Relaxin is a transforming growth factor β1 antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a pig scar model.METHODS:
Scars with full thickness were generated on the backs of Yorkshire pigs. Scars were divided into two groups (relaxin [RLX] and Control). Adenoviruses were injected into the RLX (expressing relaxin) and Control (not expressing relaxin) groups. Changes in the surface areas, color index and pliability of scars were compared.RESULTS:
Fifty days after treatment, the surface areas of scars decreased, the color of scars was normalized, and the pliability of scars increased in RLX group.CONCLUSION:
Relaxin-expressing adenoviruses improved the surface area, color, and pliability of scars. The mechanism of therapeutic effects on scar formation should be further investigated.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Relaxin
/
Swine
/
Genetic Therapy
/
Transforming Growth Factors
/
Adenoviridae
/
Cicatrix
/
Pliability
/
Therapeutic Uses
Type of study:
Prognostic study
Language:
English
Journal:
Archives of Craniofacial Surgery
Year:
2017
Type:
Article
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