Study on Serologic Test for Syphilis as a Surrogate Marker for Human Immunodeficiency Virus Infection among Korean Blood Donors / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 231-236, 2001.
Article
in Korean
| WPRIM
| ID: wpr-199454
ABSTRACT
BACKGROUND:
Serologic test for syphilis(STS) is an old traditional donor screening test for preventing transfusion-transmitted syphilis. By conducting STS, history taking for donors and refrigeration of blood, transfusion associated syphilis is very rare at present. This study evaluated the usefulness of the STS as a surrogate marker for preventing the transfusion of human immunodeficiency virus(HIV) via the transfusion of infectious window-period blood in Korean blood donors.METHODS:
Demographic and laboratory information on blood donations made between January 1997 and December 1998 in 16 Korean Red Cross Blood Centers was analyzed. STS positive rate of 239 HIV-infected people and blood donors in 1999 were investigated.RESULTS:
Of 4,808,297 donations over 2-year period, 3,956 (0.08%) were positive in STS and 40 (0.0008%) were anti-HIV confirmed positive. Of those, two were simultaneously positive for STS and anti-HIV. Among donations, Anti-HIV positive donations were 64 times more likely to be STS positive(odds ratio=63.9) and positive predictive value (PPV) of STS for anti-HIV was 0.05%. Fourteen of 239 HIV-infected people were STS positive.CONCLUSION:
STS positivity was higher in anti-HIV positive donors, but the PPV of STS for anti-HIV was low. STS as a donor screening test is considered as a poor marker for preventing post-screening HIV infections and the usefulness of STS must be evaluated in its own value.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Red Cross
/
Refrigeration
/
Tissue Donors
/
Blood Donors
/
Serologic Tests
/
Biomarkers
/
Syphilis
/
HIV Infections
/
HIV
/
Donor Selection
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Blood Transfusion
Year:
2001
Type:
Article
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