No Association between Catalase Gene Polymorphism and Gastric Carcinoma and Hepatocellular Carcinoma in Koreans / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 432-435, 2002.
Article
in English
| WPRIM
| ID: wpr-199469
ABSTRACT
PURPOSE:
Oxidative stress has been implicated in the pathogenesis of various diseases. Catalase is one of the main defense mechanisms against oxidative stress. To examine the possible relationship between oxidative stress, and gastric and hepatocellular carcinomas, HinfI restriction length polymorphism (RFLP) in the human catalase gene was assessed. MATERIALS ANDMETHODS:
The genotype and allele frequencies in the promoter region of the catalase gene were studied by PCR-RFLP in 108 Korean controls, 80 Korean gastric carcinoma (GC) and 106 Korean hepatocellular carcinoma (HCC) patients.RESULTS:
No statistically significant differences were found in the genotypic distribution and allelic frequencies between the controls and both types of carcinoma patient.CONCLUSION:
To address the possible contribution of oxidative stresses to the pathogenesis of gastric and hepatocellular carcinomas, the associations between the catalase gene polymorphism and GC and HCC susceptibilities were studied. As a result, the catalase gene polymorphism was found not to be determinant of GC and HCC susceptibilities. Further studies are required on various other oxidative stress related genes to elucidate the mechanisms of GC and HCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Catalase
/
Promoter Regions, Genetic
/
Carcinoma, Hepatocellular
/
Oxidative Stress
/
Defense Mechanisms
/
Gene Frequency
/
Genotype
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2002
Type:
Article
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