The Frequency and Distribution of the ABO Subgroups in Korean Blood Donors / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 223-229, 2010.
Article
in Korean
| WPRIM
| ID: wpr-199581
ABSTRACT
BACKGROUND:
ABO subgroups are obstacles in blood typing and cross matching in the process of pre-transfusion. Correct ABO typing is important for ensuring safety of a transfusion. The ABO subgroups contain a lesser amount of antigen on red cells and this is a common cause of discrepancy between the results of cell and serum tests. This study was performed to analyze the frequency and distribution of the ABO subgroups in Korean blood donors.METHODS:
ABO blood grouping was performed by an automated analyzer (PK7200/7300, Olympus, Japan) for the 3,397,983 donors from January 2007 to December 2009. The 1,868 donor samples that were suspected to have ABO subgroups were tested with adsorption/elution techniques. The results of the tests were analyzed and we received approval of the Institutional Review Board of the Korean Red Cross to publish this study.RESULTS:
1,771 donors out of the 1,868 donors who underwent the tests were finally identified as having ABO subgroups. The kinds of identified ABO subgroups were as follows; 118 donors with the A subgroup (A2, A3, Ax, Am, Ael), 237 donors with the B subgroup (B3, Bx, Bm, Bel) and 1,416 donors with the AB subgroup (A2B, A2B3, A1B3, AmB, A1Bm, A1Bel, AxB, A1Bx). The most frequently observed subgroups were A2B (496/1,868, 26.55%) and then A2B3 (457/1,868, 24.46%). The subgroups of 97 donors (5.19%) were not identified.CONCLUSION:
This study was meaningful to provide data on the frequency and distribution of the ABO subgroups of Korean blood donors. A more sensitive technique such as genotyping could be useful to resolve cases with an unidentified subgroup.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Red Cross
/
Tissue Donors
/
Blood Donors
/
Blood Grouping and Crossmatching
/
Ethics Committees, Research
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Blood Transfusion
Year:
2010
Type:
Article
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