Expression of bcl-2 and p53 Protein in Primary Gastric Lymphomas
Korean Journal of Pathology
;
: 978-984, 1998.
Article
in Korean
| WPRIM
| ID: wpr-199620
ABSTRACT
The bcl-2 gene is a proto-oncogene which extends cell survival by blocking apoptosis. Bcl-2 expression has been detected in many types of nodal and MALT lymphoma. The p53 gene is a tumor suppressor gene and p53 mutation is the most common genetic alteration in human malignancies. The relationship between the expression of bcl-2 and p53 protein in primary gastric lymphoma has been rarely reported. The authors investigated the expression of bcl-2 and p53 protein in 37 cases of primary gastric lymphoma by immunohistochemical method using bcl-2 and p53 monoclonal antibodies. There were five cases of low grade B-cell MALT lymphomas and thirty two cases of high grade B-cell lymphomas. Fifteen of 37 cases (41%) showed bcl-2 protein expression in the cytoplasm of tumor cells and 26 cases (70%) showed p53 protein expression in the nucleus of tumor cells. Bcl-2 protein was detected in 4 of 5 (80%) low grade MALT lymphomas, and in 11 of 32 (34%) high grade lymphomas. There was no significant correlation between bcl-2 expression and histologic grade of primary gastric lymphomas (p>0.05). p53 protein was positive in 25 of 32 (78%) high grade lymphomas, and in 1 of 5 (20%) low grade MALT lymphomas. The expression of p53 protein is significantly higher in high grade lymphoma than in low grade MALT lymphoma (p<0.05). The p53 expression in the bcl-2 negative cases (86%) was significantly higher than in the bcl-2 positive cases (47%). There was an inverse relationship between bcl-2 and p53 expression in primary gastric lymphoma. These results suggest that bcl-2 and p53 expression in primary gastric lymphoma may be involved in the transition from low grade MALT lymphoma to high grade lymphoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Proto-Oncogenes
/
B-Lymphocytes
/
Cell Survival
/
Genes, p53
/
Genes, Tumor Suppressor
/
Lymphoma, B-Cell
/
Apoptosis
/
Lymphoma, B-Cell, Marginal Zone
/
Genes, bcl-2
/
Cytoplasm
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Pathology
Year:
1998
Type:
Article
Similar
MEDLINE
...
LILACS
LIS